![]() ![]() The CPF peptides show potential for development into agents for the treatment of Type 2 diabetes.", The mechanism of action of the CPF peptides involves, at least in part, membrane depolarization and an increase in intracellular Ca(2+) concentration. No CPF peptide stimulated release of the cytosolic enzyme, lactate dehydrogenase from BRIN-BD11 cells at concentrations up to 3 μM indicating that the integrity of the plasma membrane had been preserved. In addition, CPF-SE1 (GFLGPLLKLGLKGVAKVIPHLIPSRQQ), previously isolated from skin secretions of the tetraploid frog Silurana epitropicalis, produced a significant (P <0.05) increase in the rate of insulin release at 0.03 nM with a 514 ± 13% increase over basal rate at 3 μM. CPF-7 (GFGSFLGKALKAALKIGANALGGAPQQ) produced the maximum stimulation of insulin release (571 ± 30 % of basal rate at 3 μM). CPF-1, CPF-3, CPF-5 and CPF-6 were the most potent producing a significant (P <0.05) increase in the rate of insulin release at concentration of 0.03 nM. These peptides were purified to near homogeneity and structural characterization showed that they belong to the magainin (2 peptides), peptide glycine-leucine-amide (PGLa) (1 peptide), xenopsin precursor fragment (1 peptide), and caerulein precursor fragment (CPF) (6 peptides) families. The CPF peptides show potential for development into agents for the treatment of Type 2 diabetes.Ībstract = "Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cell line. ![]() However, the very low antimicrobial activity of the magainin-AM1 and PGLa-AM2 paralogs suggests the possibility that certain peptides may have evolved toward a new, as yet undetermined, function (neofunctionalization).Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cell line. The data indicate that nonfunctionalization has been the most common fate of duplicated antimicrobial peptide genes following the polyploidization events in the X. CFP-AM1 (GLGSVLGKALKIGANLL.NH2) was the most potent peptide present in the secretions and magainin-AM2 (GVSKILHSAGKFGKAFLGEIMKS) was the most abundant. Two peptides (magainin-AM1 and -AM2) are othologous to the magainins, two peptides (PGLa-AM1 and -AM2) orthologous to peptide glycine–leucine-amide, four peptides (CPF-AM1, -AM2, -AM3, -AM4) orthologous to caerulein-precursor fragments, and one peptide (XPF-AM1) structurally similar to xenopsin-precursor fragments were characterized. laevis (2n = 36) and the diploid frog Silurana (formerly Xenopus) tropicalis (2n = 20). amieti that showed structural similarity to peptides previously isolated from the tetraploid frog X. Nine peptides with differential antimicrobial activity against Escherichia coli and Staphylococcus aureus were isolated from norepinephrine-stimulated skin secretions of X. The Volcano clawed frog Xenopus amieti Kobel, du Pasquier, Fischberg, and Gloor, 1980, with a chromosome number of 2n = 72, is believed to have undergone two rounds of genome duplication since evolving from a diploid ancestor. ![]()
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![]() ![]() This plant features large, green leaves that bear numerous plantlets along the margin. Mother of Millions ( Bryophyllum daigremontianum) And not only can the prickly thorns of this plant cause trouble for them but the milky white sap it contains in its fleshy stems can irritate the skin, and mouth, and stomach when ingested (1,2). ![]() Although the thorns can appear to be deterring for our pets, there is no guarantee that our furry critters will not mess with these plants. Crown of Thorns ( Euphorbia milii)Ĭrown of thorns is unmistakable with their sharp, pointed thorns, and striking, beautiful blooms. It could also irritate the skin upon contact (2). When ingested, the sap irritates the mouth and stomach which causes vomiting. ![]() It contains a milky white sap that is toxic to cats, dogs, horses, and humans too. This rather big succulent features fleshy, cylindrical stems that grow in a roundabout manner. It belongs to the Euphorbia genus which means it is succulent. Pencil Cactus ( Euphorbia tirucalli)ĭespite its name, pencil cactus is not actually a cactus. But like the string of pearls, they are also toxic to your pets. This adorable variety features fleshy cylindrical leaves that grow from a small, erect stem. Blue Chalksticks ( Curio repens)Īnother popular Curio variety you might want to steer from is the blue chalksticks. String of pearls has fleshy pearl-shaped leaves that contain toxic substances that can cause vomiting, diarrhea, drooling, skin irritation, and lethargy (1). But despite its cascading beauty, these plants are toxic to your pets. String of pearls is one of the most sought-after trailing succulents because of their fleshy leaves borne on long trailing stems. Most reported cases of poisoning concern livestock and horses, but dogs and cats are also susceptible, so it is best to steer away from them if you have canine and feline members in your house (1). These highly drought-tolerant succulent does not come without danger because they also contain toxic substances called bufadienolides that can cause vomiting, depression, and various cardiovascular problems when ingested. Yet another plant resembling an animal, or at least a part of it, pig’s ears are popular for their velvety oval-shaped leaves with red margins. But these pretty leaves contain toxic bufadienolides which can cause vomiting, depression, ataxia, and various cardiovascular problems (1). And to add to its adorableness is the velvety covering of the leaves. This succulent is admired for its fleshy leaves that resemble a miniature bear paw. The toxic principles of these plants are yet to be discovered but reports of poisoning include clinical signs such as vomiting, drunkenness, and, in extreme cases, tremors (1). Silver Dollar Jade ( Crassula argentea)Īnother staple and a favorite because of their attractive foliage, silver dollar jade can also cause poisoning when eaten by our pets. The clinical signs of jade plant poisoning include vomiting, depression, and ataxia (1). These Crassula ovata plants have an undiscovered toxic principle that can poison cats and dogs when ingested. Many members of the genus Crassula such as the classic jade plant pose a toxic threat to our pets. These aloe plants contain saponins and anthraquinones which can cause vomiting, lethargy, and diarrhea when ingested. While the aloe gel is considered edible and has potential medicinal properties, they can be poisonous to cats and dogs, and even horses. With their fleshy, lance-shaped leaves, aloes have become a staple plant for many succulent collections. This can be a problem for some who are new to the world of collecting succulents.Īre succulents poisonous to cats and dogs? If you are starting a succulent collection and are uncertain about which succulents are safe for your fur babies, you don’t have to worry because we have compiled some of the common types of succulents that are toxic to pets. While our pets have developed an instinctive knowledge to avoid these succulents, some of them, especially cats and dogs which are known to be quite inquisitive, could get in all kinds of trouble and mess with these toxic plants. Despite their adorable appearance, there are succulents that can be toxic to pets. There are lots of factors that you have to consider and most of them concern the requirements of the succulents such as light and water.įor some of us who have pets in our homes, it gets a lot harder because we also have to consider the safety of the furry members of our family. Starting a succulent collection can be quite daunting. Chandelier Plant (Bryophyllum delagoense) Mother of Millions (Bryophyllum daigremontianum) ![]() ![]() ![]() Textbook content produced by OpenStax is licensed under a Creative Commons Attribution License. We recommend using aĪuthors: Lynn Marecek, Andrea Honeycutt Mathis Use the information below to generate a citation. Then you must include on every digital page view the following attribution: If you are redistributing all or part of this book in a digital format, Then you must include on every physical page the following attribution: If you are redistributing all or part of this book in a print format, Want to cite, share, or modify this book? This book uses the 23) 24) 25) 26) Given two terms in an arithmetic sequence find the recursive formula. Ī n = 22 + ( n − 1 ) ( −2 ) a n = 22 + ( n − 1 ) ( −2 ) Given a term in an arithmetic sequence and the common difference find the recursive formula and thethree terms in the sequence after the last one given. The twelfth term of the sequence is 0, a 12 = 0. Ī 12 = 22 + ( 12 − 1 ) ( −2 ) a 12 = 22 + ( 12 − 1 ) ( −2 )Ī 12 = 22 + ( 11 ) ( −2 ) a 12 = 22 + ( 11 ) ( −2 ) Given a term in a geometric sequence and the common ratio find the first five terms, the explicit formula,and the recursive formula. To first find the first term, a 1, a 1, use theįormula with a 7 = 10, n = 7, and d = −2. Find the recursive and closed formula for the sequences below. Then we have, Recursive definition: an ran 1 with a0 a. Suppose the initial term a0 is a and the common ratio is r. Then you must include on every physical page the following attribution: A sequence is called geometric if the ratio between successive terms is constant. You can choose any term of the sequence, and add 3 to find the subsequent term. In this case, the constant difference is 3. 21) a n 2n + 1 n3 22) a n 4n 1 23) a n (2n)2 24) a n (2n 1)2 Find the first four terms in each sequence. The sequence below is another example of an arithmetic sequence. I Worksheet by Kuta Software LLC Find the tenth term in each sequence. For this sequence, the common difference is –3,400. Each term increases or decreases by the same constant value called the common difference of the sequence. The values of the truck in the example are said to form an arithmetic sequence because they change by a constant amount each year. 3 Versions Included:Maze 1: Arithmetic SequencesMaze 2: Geometric. In this section, we will consider specific kinds of sequences that will allow us to calculate depreciation, such as the truck’s value. Worksheets are Arithmetic sequence maze answer key, All Things Algebra curriculum. The truck will be worth $21,600 after the first year $18,200 after two years $14,800 after three years $11,400 after four years and $8,000 at the end of five years. The loss in value of the truck will therefore be $17,000, which is $3,400 per year for five years. After five years, she estimates that she will be able to sell the truck for $8,000. One method of calculating depreciation is straight-line depreciation, in which the value of the asset decreases by the same amount each year.Īs an example, consider a woman who starts a small contracting business. This decrease in value is called depreciation. To get the next term we multiply the previous term by r. The book-value of these supplies decreases each year for tax purposes. The recursive definition for the geometric sequence with initial term a and common ratio r is an an r a0 a. Use an explicit formula for an arithmetic sequence.Ĭompanies often make large purchases, such as computers and vehicles, for business use.Use a recursive formula for an arithmetic sequence. Displaying all worksheets related to - Algebra 2 Arithmetic Sequences.Find the common difference for an arithmetic sequence. ![]() ![]() ★ In collaboration with Sketchy, TONS of videos now have updated tags and images. It is not crucial to the update process, but we recommend putting your decks into two similar decks prior to updating so new cards do not import into duplicated decks (Everything needs to be spelled and capitalized exactly as follows: the Step 1 subdeck contains Lolnotacop, Zanki Pharmacology, and Zanki Step Decks and the Step 2 subdeck contains Cheesy Dorian (M3), MedicalArk, and Zanki Step 2. ![]() ★ VERY IMPORTANT The decks have been rearranged so that there is an AnKing head deck and then a "Step 1" and "Step 2" subdeck. ★ Next steps will be replacing UWorld tables as editable tables within the deck to allow information to easily be updated to reflect the newest practice questions! This is a huge project that we are just beginning to undertake now, and will take quite a bit of time and support. We have plans for replacing the remainder of the images with copyright friendly material from the web to protect the deck for future learners. B&B slides) to the additional resources field. ★ As we plan for full image support on the web application, we have moved all copyrighted materials (FA and Sketchy) to their respective fields, as well as others (UWorld, OME, Emma Holiday, misc. Additionally, “->” symbols have universally been changed to “→” ★ Syntax changes: all missing and extra line breaks (enters) in the deck have been resolved. ★ Boards & Beyond Step 2: anesthesia tags (surgery section) added (thanks to Emily DJ) Also, UWorld step 3 tags have begun to be added in as well! ★ UWorld tags: even MORE step 1 and step 2 tags! In addition, 1000+ UWorld-COMLEX Step 1 tags have been added (huge thanks to many users). A handful of Sketchy surgery completed, and a big push to have Sketchy pediatrics tags completed and integrated soon! ★ Sketchy: huge number of IM tags added (thanks to Ryan) with plans to have more soon. Most mnemonic cards have been updated for searchability to include the hint within the cloze. ★ Syntax changes: hyphens before and after clozes removed for improved readability and searchability (e.g. Working on the new Sketchy Neurology and Toxicology sections. ★ Sketchy: All of Sketchy Surgery tags completed and bulk updated (thanks Miranda!). thanks Akash!) User “a.aniekwe” helping to go through step 1 B&B tags to make sure missing cards are tagged if mentioned in the videos. ★ Boards & Beyond: Working with volunteers to bulk add more step 2 tags (recently added a lot of MSK and GI tags. ![]() Step 3 OME tags getting added in via bulk updates (thanks Kevin!) ★ OME: 50+ tag updates on blood pressure regulation, alongside several hundred microbiology tags earlier in the month. New tags being added with respective images via bulk updates every day by our volunteers. ★ Pixorize: Thousands of notes updated as the Pixorize tagging tree has been reformatted to match the website. ★ Bootcamp: nearly 10,000 new tags/video links added in. ★ UWorld tags: continuing to add step 1 and step 2 QID tags! Some incorrectly tagged QIDs removed by dedicated users. ★ OME: Continued tag updates to reflect content on step 1 and step 3 video sections. New step 1 Sketchy tags being worked on (Pharm: Buspirone tag added, new Sketchy Anatomy sections tagged and added as well!) ★ Sketchy: All of Sketchy Neurology & Toxicology tags completed and bulk updated (thanks Miranda!). ★ Add-ons we recommend to go along with this deck if you don't already have them: AnKing Note Types (Easy Customization), BetterSearch, and Edit Field During Review (Cloze). You can also rearrange the order of fields. ★ If you want the hints to show rather than having to click (or hit "h" if you have the hint hotkeys add-on), you can choose to auto-reveal them in the note styling or with the add-on. If you have the Clickable tags add-on, you can click them to bring up all other cards with that tag. ★ We added a thing that shows you the tag at the bottom of the card. You can add "edit:" to other fields if you'd like to make them editable (see our video on that add-on for how to do this). ★ We made the extra section so it can be edited with the “Edit field during review (Cloze)” add on. ![]() We will be using the other fields in future updates. ★ Moving forward, we recommend you make personal edits in the "Lecture Notes", "Missed Questions", "Pathoma" and "Boards and Beyond" fields and protect them with the Special Fields add-on for future updates. This video highlights newer updates that were eventually made. ★ This video describes html/css in detail and explains how you can customize it. ![]() ★ This new video describes the brand new AnKingOverhaul note type and the add-on that we made to make it very customizable and user friendly. ![]() ![]() ![]() The Colombian Arabica beans get a light yet long roast, resulting in subtle acidity, coffee roundness, and smooth cereal notes. The beans of Arondio roasted in two batches. There is no harshness in Arondio, and it allows you to jumpstart your day with positive thoughts. This blend brings clean strength and balanced intensity to the last. Nespresso Arondio Vertuo coffee capsule is a blend of Colombian Arabicas and Guatemalan-washed Robusta beans. Origin - Colombian Arabica and Guatemalan Robusta These features also help us to understand when we should brew this lavish pod. These attributes differentiate Arondio from all other Nespresso Vertuo coffee pods greatly. I focus on the major features of the Nespresso Arondio Vertuo pod. Arondio Decaffeinato FeaturesĪrondio is a medium roasted blend with distinct cereal notes. I suggest this incredible Vertuo coffee pod greatly. Overall, I got decent flavor, the flowery and fruity were coming through, and I felt a little bitterness on the tip of my tongue. It was interesting the first taste was reasonably strong and hit my palate hard. I felt the toasted and corn cereal flavor. The fruity and flowery notes disappeared, and I got mild cereal notes. I tried gran lungo Arondio with milk I frothed the milk with Aeroccino milk frother and added it to the brewed Arondio drink. After some time, the flowery notes fainted, and a little nip of bitterness took its place. I took another sip and felt the flowery essence. I felt a few fruity notes and a bitter aftertaste indicating the presence of dark and long-roasted Robusta beans. When I tasted it, the flavor was astonishing to me. Its color indicated that its intensity would be around 6. When I smelled it, I felt a tart scent and found it interesting. The coffee dripping was soothing, and I was excited to taste it. It is a VertuoLine pod and delivers 5.7 oz gran lungo, so I brewed it with a VertuoLine machine. When I unboxed my Arondio Vertuo pod, it was pretty good. Arondio Nespresso Medium Roasted Blend Taste Test It delivers the perfect cappuccino and makes your day perfect with subtle acidity, enchanting character, and a little bitterness. When you brew it without milk, you get flowery and floral notes, but when you add milk, a smooth cereal note graces your palate. ![]() It is created from Colombian Arabicas and a touch of long roasted Robusta oomph. What Flavor Is Arondio Gran Lungo?Īrondio gran lungo has a remarkable flavor range. This split roasted coffee hits your palate with malty and nutty notes and gives you a lovely experience with or without milk. It delivers a 5.7 oz balanced gran lungo drink and allows you to kick start your day with one of the best Nespresso coffees. Nespresso Arondio is a medium roast coffee made from the medium roasted blend of Colombian Arabicas and Guatemalan-washed Robusta beans. Read More Nespresso Buying Guides From Coffee AimĬheck its current price on Amazon → What Is Arondio? Arondio Meaning.How much caffeine is in a Nespresso Arondio?.Is Arondio Gran Lungo Mild Coffee for You?.Nespresso’s AAA Sustainable Quality Program.What Nespresso Machines Are Compatible With Arondio Vertuo Pod Nespresso capsules?.How Much Caffeine Is In A Nespresso Arondio Vertuo Pod?.Arondio Nespresso Intensity - 6 out of 14.Origin - Colombian Arabica and Guatemalan Robusta. ![]()
![]() There is always something going on at Blue Back Square. Teens and Tweens can explore their creative side in these fun indoor spaces. Photo courtesy of Muse Paint Bar at Blue Back Square 14. In addition to shops, the SoNo Collection is also home to Pinstripes Bowling and Bocce, Galaxy VR, and a steady rotation of live entertainment events. SoNo Collection - NorwalkĬonnecticut’s newest mall is filled with a ton of entertainment options. Scout & Molly’s, Shake Shack, Sephora, and Dude’s Donuts are some of our favorite spots to hit. With tons of places to shop til you drop, you can easily do some damage to your wallet at the Shops at Evergreen Walk. The Promenade Shops at Evergreen Walk - South Windsor With a wide selection of flavors, it may be hard to pick a favorite.įun Indoor Places in Connecticut for Teens and Tweens: Malls & Shopping Centers 12. The menu is broken down to three categories: bubble teas, sweet crepes, and mochi ice cream. This bubble tea/crepe shop is located in the heart of Norwalk’s Wall Street neighborhood. Tables, cozy couches, and a selection of games make this the perfect spot to hang out. The Loaded Goat prides itself on being “the spot for bringing local people together” A fun menu is filled with hot drinks and cool treats the perfect combination. Tween- and teen-friendly restaurants make great indoor spaces to hang out. Photo courtesy of The Loaded Goat 10. Of course, end the meal with a famous milkshake! Their social media superstars items include PB&J pancakes, cereal bowl French toast, bacon mac & cheese curly fries, and lots more. The third Saturday of every month is reserved for Coffee House Sessions, where you can enjoy music by local Connecticut artists. This lovely cafe is home of weekly open mic nights for tweens, teens, and adults. Let your teens stage their skills at an open mic night in CT! Photo courtesy of Nightingale's Acoustic Cafe 8. Pistachio also has an eclectic mix of coffee beverages, teas, lattes, hot chocolates, and just about anything else. Bonus Points: almost everything on their cocktail menu can be turned into a teen-friendly mocktail.Ī fun mix of paninis, waffles, wraps, and Middle Eastern fusion cuisine, the food at this spot is almost too pretty to eat. S’more pancakes, fried chicken sandwiches, and a drink menu that is almost too good to believe. This Connecticut spot whips up brunch like no other. The Place 2 Be is, well, THE place to be. The Place 2 Be - West Hartford, Hartford, New Haven Fun Indoor Places in Connecticut for Teens and Tweens: Coffee Shops and Restaurants 6. To find even more arcades, go-karts, and indoor fun near you, check out our Indoor Fun Guide. The music, the disco ball, the slurpee machine-there is something so nostalgic about a roller rink. Gliding across the shiny floors of Rollermagic is still the perfect way to spend a Friday night with your friends. In nice weather, head outdoors to the batting cages and mini golf.įood and fun await Connecticut teens and tweens at these indoor spots. Photo by Ally Noel 5. Check out their indoor arcade, bowling, laser tag, target paintball, ice skating. The Sports Center of Connecticut has both indoor and outdoor options to keep your teens entertained all year long. But, that’s not all! There are trampolines, axe-throwing, video games, a ninja course, and brick oven pizza-yum! 4. Supercharged is home to the WORLD’S LARGEST multi-level indoor karting track. And there is a ton to pick from! VR, laser tag, bowling, black light mini golf, rock climbing, and more. A huge bonus: there is no entrance fee, so you pay only for activities that you want to do. Nomads is a huge indoor entertainment facility featuring 65,000 square feet of fun. ![]() ![]() Las expectativas en su año sophomore apuntan a una relevancia aún mayor, teniendo en cuenta los problemas en la pintura de los Heat. During a stretch of games in which Davis was sidelined, Bryant averaged 16.9 points per game and 10.5 rebounds over a 13 game stretch. En su primera temporada en la NBA, Yurtseven promedió 5,3 puntos, 5,3 rebotes y 12,6 minutos en 56 partidos, doce de ellos como parte del quinteto inicial. He had moved into the starting lineup in place of the injured Anthony Davis and was putting up phenomenal numbers. ![]() Prior to being traded to the Nuggets, Bryant was one having one of the best seasons of his career with the Lakers. Nuggets head coach Michael Malone prefers to run a tight rotation. That's not indicative of his ability to contribute. By the time the playoffs rolled around, he was pretty much out of the rotation. He didn't play much for them during the second half of the season after he was acquired in a trade with the Lakers at the deadline. Thomas Bryant was actually a member of the Nuggets this past season. But the Heat needed to go and get more experienced option and they did just that. The Heat do have a couple of players in Nikola Jovic, Omer Yurtseven and Orlando Robinson who could conceivably become key frontcourt contributors. It was an issue they faced back in the 2020 Finals against the Los Angeles Lakers as well with Adebayo back then being their only option to match up with the Lakers frontline. Behind Bam Adebayo, the Heat just didn't have the necessary bodies up front. One of the issues the Heat faced in their 2023 NBA Finals series against the Denver Nuggets was their lack of size. But while they're playing the waiting game on how the Blazers intend to proceed, the Heat's top move of free agency so far has been the signing of backup center Thomas Bryant. The Heat didn't have much cap space to spend in NBA free agency so pulling off a trade for Lillard would certainly be their best move of the offseason. The Miami Heat find themselves in an interesting situation as they are considered the frontrunners to land Portland Trail Blazers star Damian Lillard. ![]() NBA free agency is starting to wind down with most teams having made all of their key offseason moves. Yurtseven split time between high school studies and the Turkish pro team, Fenerbahce, and once appeared in an NBA exhibition game between Fenerbahce and. ![]() ![]() ![]() See all tasks with any label that starts with “home”. To filter for several items with similar characters, you can use a wildcard by placing an asterisk in your search term. For example, the filter query will pull up a list of all tasks that have a label that ends with the word “ball”, like and are some more examples of how you can use wildcards in filters: If you need to #Homework & tomorrow & wildcards in filters See all tasks that are due tomorrow in the “Homework” project, but exclude tasks with the label See all tasks that are due today but exclude tasks in the "Work" project See all tasks that are not assigned to anyone See all tasks that are due today and are also labeled & all tasks that are labelled either or | all tasks that are either due today or are overdue and are also in the “Work” project You can combine any filter query you want to get the exact view you need. ![]() When you search for tasks assigned to or by one of your collaborators, make sure that you use the name the collaborator uses in Todoist.įor example, Steve's real name might be Stephen Gray, but if he is listed as "Steve Gray" in Todoist, you should search assigned by: Steve Gray or assigned to: Steve Gray.Ĭombining queries to create more powerful filters See all tasks created within the last 365 days See all tasks created more than 365 days ago See all tasks not assigned to sections, but excluding tasks in your Inbox See all tasks belonging to the section "Meetings" in the project "Work" See all tasks belonging to sections named "Meetings" across all projects See all tasks in the "School" project and its sub-projects, but exclude the "Science" project See all tasks in the "Work" project and its sub-projects Project, sub-project and section If you need to See all tasks with the label all tasks that don't have any labels See all tasks with no priority level (i.e. Days of the week: Monday, Tuesday, Sunday.Relative date: today, tomorrow, yesterday, 3 days (due in the next 3 days), -3 days (due in the past 3 days).Specific date and time: 5pm, Oct 5th 5pm.You can write a date in any of these ways: See all tasks with a due date, but no due time, and which are not recurring See all tasks that either have a non-recurring due date or no due date at all assigned to them See all tasks that have a recurring due date #Inbox & no date, All & !#Inbox & !no date See all tasks in your Inbox without a date, followed by a separate section with all your tasks that have due dates set, but are not in your Inbox See all tasks that are overdue and have had a specific time assigned to them, along with all tasks due today, but only with due times See all tasks with a due date and time assigned to them See all tasks with a due date assigned to them See all tasks that have no due date associated with them See active tasks due yesterday, along with today's tasks listed below See all tasks due within the current calendar month (due: next week | due after: next week) & due before: 1 week after next week See all tasks with a due date in the current working week See all tasks that are due before the day you've selected in Settings > General > Next week See all tasks due within the next four hours and all overdue tasks See all tasks that are due after a specific date ![]() See all tasks that are due before a specific date See all uncompletable tasks that contain web links See all tasks that contain the word "email" See all tasks that contain either the word "Meeting" or "Work" See all tasks that contain the word "Meeting" that are due today See all tasks that contain the word "Meeting" In order to create filters based on keywords, you can use search: followed by a keyword. ![]() ![]() Choices include the JR East Pass (Tohoku), the JR Tokyo Wide Pass (Area surrounding Tokyo), the JR West All-Area Pass (Western Honshu), as well as passes covering Kyushu, Shikoku, and Hokkaido. If you’d rather concentrate on seeing one area, a regional pass is a good bet. Note that passes are only open to foreign visitors, and cannot be purchased by residents of Japan or those with Japanese passports. You should order your passes well in advance of your trip, as shipping can take a while. Before the increase, the pass is excellent value after the hike, the pass is still a good choice if you want to travel all over Japan, visit several different places, and plan to spend no more than a few days in each location. Note that the price will rise in October 2023 to ¥80,000 ( £457 $575) for a 14-day pass. The current price for a 14-day adult pass purchased outside of Japan is ¥47,250 (£275, $341) ¥52,960 (£302 $380) if purchased inside Japan. The best pass for visitors is the Japan Rail Pass or JR pass, an all-inclusive ticket covering almost any Japan Rail train in the country – including most high-speed trains. I’ve traveled extensively from north to south using Japan’s famously efficient, modern rail system, which reaches nearly every corner of the country.įor maximum freedom and flexibility, a rail pass is a great way to go. There’s no more natural way to travel in Japan than by train. Do treat this as a guide and feel free to go your own way – that’s the flexibility the Japan Rail Pass can offer (more on that below). Spoiler: some of the best places in Japan are the ones that you stumble upon in between hitting the major attractions. You’ll travel the length of Japan’s main island of Honshu and experience the onsen island of Kyushu, visiting craftspeople, rolling through rice paddies, marveling at mountain temples, feasting on local specialties like okonomiyaki – and much, much more. ![]() This two-week Japan itinerary takes you on a round-trip from Japan’s delightfully disorienting capital, whisking you from castle towns in the north to the cities of Osaka, Kyoto and Hiroshima in the south – and finishing off with a relaxing break in the hot spring town of Beppu. Using the Japan Rail pass, you can take in the lights and buzz of Tokyo before experiencing the country’s rich local culture. What I will say is that two weeks in Japan will never feel like enough, but makes for a great introduction to this endlessly fascinating country. You can relish international cuisine at CafeRest'Cuzn Home GRound located approximately a 5-minute walk away.It’s cliché to say you could spend forever in Japan and not get bored. The Asakusa Kokono Club Tokyo offers on-site breakfast in the restaurant. A bidet, a tub and a shower, along with a hair dryer and shower caps, are provided. ![]() Asakusa Kokono Club Hotel is also adjacent to a train station.Ĭomprising a balcony and a dining area, the rooms at this Tokyo property are equipped with a flat-screen TV with satellite channels. A family vacation to Tokyo will become more exciting if you visit the 14.3-hectare Ueno Zoo lying around 25 minutes' walk from the accommodation. The hotel is located amidst many restaurants, eateries and bars, and just a short stroll from the historic Senso-ji Temple. The nearby sports attractions include Ryogoku Kokugikan Sports Arena, 5 minutes by car from the property. This budget hotel in Taito, which is Tokyo's museum and Tokyo's art district is about 10 minutes' drive from the large Ueno Park and within 7 km of such shopping venues as the Traditional Tsukiji Wholesale Market. ![]() The 3-star Asakusa Kokono Club Hotel Tokyo offers 30 rooms within a 6-minute walk of Asakusa Shrine. ![]() ![]() They are mostly inspired by multiple anime shows and games from their childhood.When they stream, they mostly draw art and answer their viewers' questions.OMOCAT's favorite character in their game, OMORI, is BASIL. When Omocat set up the Kickstarter for Omori back in 2014, they promised that the game would feature 'really long gameplay.' Boy, did they deliver.This was an old controversy yet still gets brought up on Twitter. This response wasn't well received, so they came out with an apology basically stating that they didn't know that "shota" meant the same thing as "shotacon". Original Story Thu 3rd Dec, 2020 13:30 GMT: Those of you with good memories might recall an indie title by the name of OMORI, which was successfully funded via Kickstarter way back in 2014. Shota isn't exclusively erotic I'm not a pedohpile, nor an ableist, nor a scammer, nor a racist, so stop calling me those things. The warmest thing here is probably your laptop. A black lightbulb hangs from the ceiling wherever it is. Everything is bright white there arent any walls. They were also 22 at this time, which only made this situation worse. Your name is OMORI and youve been living here for as long as you can remember. This instantly gave them a bad reputation. This, alongside the fact that their original OMORI drawings had him watching pornography, led to OMOCAT being called a "shotacon" on Twitter. In 2014, OMOCAT came out with a shirt that had the word "shota" on it. Despite the backlash of the game being delayed for six years, the game itself had an overwhelmingly positive response and it was worth the long wait for the community. Later, OMOCAT finally came out and stated that the game would release in 2020, which it did on December 25th of that year. They threatened legal action and threatened to file a lawsuit against OMOCAT fortunately, this wasn't the case. The controversy started when OMOCAT shared little to no details about the game's production, and when the game eventually didn't release in 2017, fans came to the conclusion that they were being scammed. A Kickstarter campaign was launched in, and was successfully funded within one day. OMOCAT garnered a lot of controversy as the original Kickstarter and game trailer for OMORI were out in 2014, and the game was originally planned to be released in 2015, but the date was changed to 2017. Omori Aubrey Anime Cosplay costume jacket size L. The game was also ported to the Nintendo Switch in a highlighted section of a Nintendo Indie World direct.Ĭontroversy Game Development Extension and Delayed They started a Kickstarter for the game with a $22,000 goal, but it unexpectedly blew up and raised a whopping $203,300. They later changed this, as their true vision was for OMORI to be a video game that told a tragic tale. It was originally going to be named Omoriboy. ![]() At first OMOCAT wanted to use their art skills to make OMORI a manga. OMORI is OMOCAT's well known video game project. Omocat doesnt even list the game as an ongoing project on her website, listing it as 'OMORI RPGMaker Game (2014-2016)'. Theres nearly no marketing, no clear or definite communication regarding progress, and almost no interaction with backers/fans. 2.1 Game Development Extension and Delayed Its all just really frustrating for fans. ![]() |
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